Chemabrasion for the treatment of perioral wrinkles: clinical analysis and epidermal Langerhans cells qualifi

Introduction: Skin photoaging can be treated with ablative therapies that may cause immunological changes to the skin. Objective: To evaluate the results of chemabrasion in the treatment of perioral wrinkles and the change in number of Langerhans cells. Material e methods: Application of 35% trichloroacetic acid followed by manual dermabrasion using waterproof sandpaper in 12 female patients with perioral wrinkles. The patients were evaluated 30 days and 1 year after surgery. Immunohistochemistry was used to measure Langerhans cells, which were counted before treatment and 1 month post-treatment. Results: Improved perioral photoaging and reduced number of Langerhans’ cells (p = 0.002) were seen in all patients. Conclusion: Chemabrasion provides effective results in the treatment of perioral wrinkles but Langerhans cells remain low for 30 days after therapy.